Bilinearity in Spatiotemporal Integration of Synaptic Inputs
Figure 8
Dendritic integration of a pair of inhibitory inputs.
(A–D) Simulation results. Two inhibitory inputs are given at the location and at
. (A) The SC amplitude is plotted against the product of the two IPSP amplitudes, at the time
when one of the IPSPs reaches its peak. Varying
and
less than
, it can be seen that
increases linearly with
. (B) Dendritic integration in the time interval
. (upper)
for the goodness of the linear fitting of
vs.
at different times. (lower) The shunting coefficient
(in the unit of
) as the slope of the linear fitting is plotted at different times. The error bar indicates
confidence interval (The error bars are relatively small). The circle marked by red indicates the case in (A). (C–D) The same as (A–B) except that one of the IPSPs is elicited
earlier than the other. (E–H) Experimental results with two inhibitory inputs given at the location
and at
. (E–F) for concurrent inhibitory inputs and (G–H) for nonconcurrent inhibitory inputs with arrival time difference
.