The Pharmacodynamics of the p53-Mdm2 Targeting Drug Nutlin: The Role of Gene-Switching Noise
Figure 5
Nutlin pharmacokinetics: Data from Zhang et al. [58] (total Nutlin concentration in mouse retina after oral delivery, black dots), and fittings by the model (8).
Doses: panel A, 100 mg/Kg; panel B, 200 mg/Kg.