The Pharmacodynamics of the p53-Mdm2 Targeting Drug Nutlin: The Role of Gene-Switching Noise
Figure 2
Percentage of cells viable after exposure to different Nutlin concentrations.
Symbols: experimental data from Vassilev et al. [6]. Solid and dotted lines: models predictions. In the simulation, cell viability was evaluated 48 h after the start of exposure. The response of 500 cells was simulated for each Nutlin concentration.