Dissecting Dynamic Genetic Variation That Controls Temporal Gene Response in Yeast
Figure 3
Comparative performance analysis on synthetic data.
Shown is the accuracy measure (scatter plots, left) and an example (histograms, right) across compared methods and different synthetic data parameters. Left: The accuracy measure (y-axis) using different patterns of genetic effects (impulse, single state-transitioning (sustained), linear, and complex sub-panels). Results are shown over genes that were measured in different numbers of time points (measures were averaged over effect sizes; x-axis, A), or over genes of different effect sizes (averaged over time points; x-axis B). Plots depict six alternative mapping methods (color coded). Right: Examples of performance (y-axis) using the four different dynamic effect patterns (color coded) across various methods (x-axis) for nine time points (A) or for genetic effect size 0.5 (B). The plots indicate that for non-linear genetic effect patterns, DyVER has an advantage over existing methods.