Dissecting Dynamic Genetic Variation That Controls Temporal Gene Response in Yeast
Figure 1
Temporal genetic effect patterns.
Schematic view of gene expression patterns (top) and the relevant temporal genetic effects for these genes (bottom). The cartoons demonstrate a non-dynamic genetic effect pattern (A), a dynamic, linear genetic effect pattern (B), and a dynamic, non-linear genetic effect pattern (C). Top: shown are gene expression levels (y-axis) during a response to stimulation (x-axis). Each curve represents measurements in a different homozygous animal strain (segregants), where brown or black indicates whether the genotype of the associated genetic variant is or
, respectively, in each strain. Bottom: shown are genetic effects (that is, the change in gene expression between the
-carrying and
-carrying strains, y-axis) during a response to stimulation (x-axis). (C) Examples of non-linear genetic effect patterns, which are the focus of this study, including (left to right) a single state-transitioning pattern, which may be followed by a sustained new level of genetic effect, a single-pulse (impulse) pattern, and a multiple-pulse (complex) genetic effect pattern.