Highly Loaded Behavior of Kinesins Increases the Robustness of Transport Under High Resisting Loads
Fig 10
The transport of the cargo in the presence of obstacle is depicted.
(a) depicts transport when a static obstacle (shown as a triangle) is on the path of the cargo. (b) shows a moving obstacle (shown as a rectangle) approaching the cargo. The cargo moves backward with velocity of vobs due to the moving obstacle. Fk,1 and Fk,2 are forces (acting on the cargo) of two kinesins. The cargo overcomes the obstacle when the sum of those two forces is larger than Fobs. (c) and (d) present the probability Poc that the cargo overcomes one obstacle without unbinding from the MT. (c) shows the probabilities for static obstacles which require forces of 10, 15, and 20 pN to be overcome it. (d) shows probabilities to overcome moving obstacle when the cargo is retrograded by the obstacle with the velocity of 200 nm/s.