Structure, Dynamics and Implied Gating Mechanism of a Human Cyclic Nucleotide-Gated Channel
Figure 4
The cross-correlations between the residues in each motion type are shown on the left panels (A, C, E); the channel is colored according to the correlation of the VSD of chain A with the other residues. The corresponding motions are presented on the right panels (B, D, F). Snapshots are colored according to the direction of motion, ranging from green to red. (A, C, E) In each panel, chain A represents an arbitrary CNGA3 chain (the channel comprises four identical chains). The magnitude of positive and negative correlations between the fluctuations of the residues is color-coded according to the blue-to-red scale at the bottom of the picture. Positive correlation indicates motion of two residues in the same direction, while negative correlation indicates motion in opposite directions. In panel A, the arrows indicate the location of the pivot points of the rotational motion at the termini of the S6 helices, i.e., the border between the dynamics units (See Discussion). The CNBDs in panel D and the TM domain in panel F are omitted for clarity.