Structure, Dynamics and Implied Gating Mechanism of a Human Cyclic Nucleotide-Gated Channel
Figure 2
The evolutionary conservation profile supports the model structure.
The channel is colored by conservation grades according to the color-coding bar, with variable-through-conserved corresponding to turquoise-through-maroon. Overall, the variable residues are peripheral, whereas the conserved residues are in the structural core and channel pore. (A) Side view of the model structure in cartoon representation; the CNBDs are in their holo-state. (B) Extracellular view of the TM domain of the model structure. The proposed locations of the two CNGA3 and two CNGB3 subunits are marked [7].