Comprehensive Sieve Analysis of Breakthrough HIV-1 Sequences in the RV144 Vaccine Efficacy Trial
Figure 7
Mapping of signature sites and sites under selection on an Env trimer structure.
Trimer (PDB id: 4NCO [27]) is shown in surface representation, with gp120 in grey and gp41 in dark grey. (a-e) Panels correspond to the five physico-chemical properties analyzed for evidence for property importance: (a) chemical composition, (b) polarity, (c) volume, (d) isoelectric point or (e) hydropathy [25]. Signature sites identified in Env-gp120 are colored in green, and sites that were under selection are colored from pink to red (corresponding p-values from 0.05 to < 0.0001). (f) Visualization of the major sites of vulnerability on the HIV-1 Env.