Embryonic Stem Cell Specific “Master” Replication Origins at the Heart of the Loss of Pluripotency
Figure 5
Genome-wide spatial distribution of chromatin states in ESCs and differentiated cells.
MRT profile along two Mb long fragments of human chromosome 5 (left) and 14 (right). U-domains are marked by an horizontal orange line and their borders by vertical red lines. Below the MRT profile, gene positions are indicated by a horizontal segment (blue: not expressed, orange: expressed) as well as the chromatin state of each 100 kb window is represented using the same color coding as in Fig. 2. At the bottom of the plot, intervals significantly enriched in H3K27me3, H2AZ and CTCF are represented in black. At the bottom of the figure, the last panel represents the compositional skew [79–82] in 1 kb windows of repeat masked sequences; germline replication skew N-domains are marked by an horizontal orange line and their borders by a vertical red line.