Embryonic Stem Cell Specific “Master” Replication Origins at the Heart of the Loss of Pluripotency
Figure 1
Spearman correlation matrix between epigenetic marks in H1hesc (top) and Nhdfad (bottom).
For each cell line, we computed the Spearman correlation over all 100 kb non-overlapping windows with a valid score. Spearman correlation value is color coded using the color map shown on the left. Lines for the epigenetic marks were reorganized by a hierarchical ordering using Spearman correlation distances [Equation (1)] as illustrated by the dendrograms on the right of the corresponding matrices. This ordering implies that highly correlated epigenetic marks are close to each other.