Glutamate Mediated Astrocytic Filtering of Neuronal Activity
Figure 8
Model astrocytes display a coupling degree-dependent onset.
A, Single-cell astrocyte responsiveness as a function of stimulation frequency and for different coupling degrees (i.e. number of unstimulated astrocytes to which the stimulated one is coupled). B, Normalized derivatives ((dR/dfs)/max(dR/dfs)) of the curves in A; peak values are denoted by stars (exact onset frequencies). Isolated astrocytes (k = 0, blue line) display a fast increase in responsiveness just before 2 Hz while astrocytes which are linked to one astrocyte (k = 1, green line) have a much later onset, around 5 Hz. For k = 2, red line the exact onset frequency is above 10 Hz.