Glutamate Mediated Astrocytic Filtering of Neuronal Activity
Figure 7
Model astrocytes also respond in a frequency-dependent manner to neuronal stimulation.
A, Astrocyte calcium signals (green traces) show a variety of responses, as in the experiments. Some of them start responding at frequencies as low as 2 Hz (top trace) while others need up to 20 Hz to elicit a significant response (bottom trace). Astrocytes were stimulated using the red neuronal spike train, stimulation frequencies are indicated on top of the figure. B, Using the same method as in the experiments (Fig. 3C), population responsiveness was computed in the simulations and plotted as a function of stimulation frequency for all modeled cultures. Grey circles denote population responsivenesses and black dots their average value. Error bars indicate standard error and the black dashed line shows the sigmoidal fit characterizing the frequency-dependent astrocyte response (n = 130 cells).