Molecular Dynamics Study of the Opening Mechanism for DNA Polymerase I
Figure 6
The O-helix distance as measured by the α-C distance between Arg629 and Pro699 depicting the opening of the fingers domain for the wild-type 1LV5 (blue) and R703A mutant (purple) simulated using Desmond and the Charmm27 force field.
The plot shows the mutant reaching the open conformation in <50 ns, while the wild-type does not open fully until ∼290 ns.