A Reaction-Diffusion Model of Cholinergic Retinal Waves
Figure 5
Modeling biophysical manipulations.
A. Synaptic connection strength is varied. Sub plots from left to right: speed of wave front
at rest (when
) as a function of conductance
, velocity indicates maximum wave-front speed since
and
is monotonically decreasing, point at which
becomes zero represents excitability threshold; wave-front speed as function of refractory variable
for three different values of
; from 5000 s of simulation of model with indicated values of
interwave-inteval; wave speed distribution; and mean wave size. B. Sub plots from left to right: dynamics of refractory variable
of individual SAC following depolarization with different sAHP timescales
, black line indicates refractory value above which
and thus represents an absolute refractory time period in which SAC is not sufficiently excitable to participate in future wave activity; from 5000 s of simulation of model with indicated values of
inter-wave interval; wave speed distribution; and mean wave size.