A Reaction-Diffusion Model of Cholinergic Retinal Waves
Figure 1
Starburst amacrine cells obey Morris-Lecar dynamics with voltage term , refractory variable
, sAHP variable
and acetylcholine concentration
. A. Time course of individual SAC dynamics following current injections of indicated size, injected at
for 1.5 s (shown in grey). Model SACs' refractory period shows dependence on amount of current injected. B. Single cell dynamics showing sparse spontaneous depolarizations. Different colors represent different SACs. C. Distribution of inter-event intervals in stochastic simulation of isolated SAC. A threshold of −50 mV was employed. Bar plot shows mean and standard deviation.