Dynamics from Seconds to Hours in Hodgkin-Huxley Model with Time-Dependent Ion Concentrations and Buffer Reservoirs

doi:10.1371/journal.pcbi.1003941

Dynamics from Seconds to Hours in Hodgkin-Huxley Model with Time-Dependent Ion Concentrations and Buffer Reservoirs

Figure 4

Fixed point continuation.

Fixed point continuations for a range of impermeant intracellular chloride concentrations in (a), (b) the –plane and (c), (d) the –plane. The black curves are the stable FES branches that lose their stability in Hopf bifurcations (black circles). Starting from the leftmost fixed point curves the fixed values are 8, 12, 16, 20, 24, 28 and 32 mM for the reduced model and 9, 13, 17, 21, 25, 29 and 33 mM for the detailed model. The Hopf bifurcations for different chloride concentrations lead to the blue Hopf line. As a reference the fixed point curves from Figs. 2 and 3 are also included in the diagram and drawn in grey.

doi: https://doi.org/10.1371/journal.pcbi.1003941.g004