ECOD: An Evolutionary Classification of Protein Domains
Figure 13
Structures of homologous members of the FZ-CRD (A,B), glypican (C), folate receptor (D), and NPC1 (E).
Conserved disulfide bonds are shown in pink sticks with labels by their sides. Four core helices are labeled H1–H4. N- and C-termini are shown. Homology detected by distinct cysteine residue patterns was used as the basis for merging these families into a homologous group (H-group) in ECOD. F. Pairwise Dali Z- scores between pairs of the structures. G. Multiple sequence alignment of the structures shown, with conserved cysteines highlighted on black background. Cysteines forming a disulfide bond are labeled by the same sign for FZ-CRDs from Frizzled8 and MuSK (line above the sequences) and glypican, folate receptor and NPC1 (line below the sequences). Four core helices (H1–H4) are shown below the alignment in cylinder representation.