ECOD: An Evolutionary Classification of Protein Domains
Figure 5
Classification methods used for non-redundant (NR) chains for weekly ECOD updates.
“Automatic” chains could be completely and confidently classified by domain pipeline and required no manual intervention. “Manual” chains were at best partly classified by software and required manual curation (i.e. some domain boundaries could not be properly detected or some domains could not be reliably classified using sequence methods). Non-domain” chains contained peptides, coiled-coils, or other cases requiring manual curation.