BiomeNet: A Bayesian Model for Inference of Metabolic Divergence among Microbial Communities
Figure 3
Inferred metabolic composition of carnivore, omnivore and herbivore gut-microbiomes.
Mammalian microbiome samples are mapped to three metabosystems and plotted on a simplex (de Finetti diagram). Each point within the simplex represents a sample having a unique set of proportions for the 3 metabosystems. The proportions for each sample sum to one. Lower left, lower right and top corners of the simplex plot indicate 100% membership to metabosystems 1, 2 and 3 respectively. Carnivore (magenta) and herbivore (green) samples are plotted in the large simplex, and omnivore (black) samples are plotted in the small simplex. Each metabosystem is represented in terms of 19 principal subnetworks by using a “composition ribbon” along the sides of the large simplex. Metabosystem 1 and its principal subnetworks are plotted along the horizontal side of the large plot. The colored bars represent the membership of the subnetworks to this metabosystem. The other two sets of grey bars represent the membership of the same subnetworks in the other two metabosystems for comparison. Bold labels indicate the discriminatory subnetworks. One subnetwork, 49, was highly discriminatory for metabosystem 1. It is easy to see from the composition ribbon that subnetwork 49 is substantially more abundant in metabosystem 1 compared to the other two metabosystems. The criteria for selecting principal subnetworks and discriminatory subnetworks are provided in Text S3. Composition ribbon plots for all 100 subnetworks can be found in Text S7.