Phosphate Sink Containing Two-Component Signaling Systems as Tunable Threshold Devices
Figure 2
The effect of parameter changes on the “sigmoidality” of the signal-response curve.
The level of sigmoidality, Hill coefficient, is shown as a heat map on each panel. (A) Effect of varying the forward and reverse phosphotransfer rates for the sink RR (CheY1; x-axis; kS and y-axis; krS). (B) Effect of varying the total concentration of the output RR (CheY2; y-axis) and sink RR (CheY1; x-axis). (C) Effect of changing the phosphotransfer rate (ks) from CheA to the sink protein (CheY1) on the signal response curve. Each curve is coloured to match the parameter values indicated by the coloured spots on the heatmap shown in panel (A). (D) Effect of changing the concentration of the sink protein (CheY1) on the signal response curve. Each curve is coloured to match the parameter values indicated the coloured spots on the heatmap shown in panel (B).