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Estimating HIV-1 Fitness Characteristics from Cross-Sectional Genotype Data

Figure 6

Treatment outcome with ZDV+IDV dual therapy.

A. Genotypic reasons of treatment failure were assessed in terms of mutations present at point of virological failure. For different combinations of drug efficacies and , the different genotypic reasons of failure are shown in different colours. The treatment outcome could be a) failure with mutations resistant to both ZDV and IDV, (b) failure with mutations resistant only to ZDV, (c) failure with mutations resistant only to IDV, (d) failure with wild type, and (e) no detection of failure. B. Viral load (in copies RNA/ml) under ZDV+IDV therapy with = 0.75 and = 0.90. The blue line shows the total viral load, while the red dashed line depicts the wild type. The horizontal black dashed line represents the detection threshold used (500 copies/ml).

doi: https://doi.org/10.1371/journal.pcbi.1003886.g006