Estimating HIV-1 Fitness Characteristics from Cross-Sectional Genotype Data
Figure 2
Fitness costs, resistance factors, and selective advantages of mutants arising under ZDV therapy.
A. Estimated fitness costs (normalized by setting fitness cost of wild type to 0), B. Resistance factors (normalized by setting resistance factor of wild type to 1), on a logarithmic scale, and C. Estimated selective advantages (normalized by setting selective advantage of wild type to 1) of ZDV mutants. In A, B and C, the x-axis depicts the number of mutations. The TAM-1 mutants (joined by blue solid lines) are to the left and TAM-2 mutants (joined by red solid lines) are to the right of the wild type. The mixed mutants (joined by black solid lines) are to the left of the TAM-1 mutants. The TAM-1, TAM-2 and mixed mutants are separated by vertical dashed lines.