Reconstruction of the Gene Regulatory Network Involved in the Sonic Hedgehog Pathway with a Potential Role in Early Development of the Mouse Brain
Figure 5
Model of Shh-mediated pattern formation in early mouse brain.
Shh+Ptch1− and Shh−Ptch1+ domains are colored by light red and light blue respectively. Broken line with triangular arrow indicates the diffusion of Shh. Solid line with triangular arrows represent up-regulation while circular arrows represent down-regulation. Two pathways of GLI regulating Gata3 may exist: direct regulation of Gata3 by Gli1/2 (pathway 1)was based on promoter analysis and indirect regulation of Gata3 by GLI through Nkx2.2 as proposed by Craven et al. [56].