Reconstruction of the Gene Regulatory Network Involved in the Sonic Hedgehog Pathway with a Potential Role in Early Development of the Mouse Brain
Figure 3
The relationship of Gata3 and Foxa2 targets with Shh+Ptch1−-/Shh−Ptch1+-pattern genes.
(A) The overlaps between Foxa2 targets in ChIP-seq with ABA ISH annotations and Shh+Ptch1−-/Shh−Ptch1+-pattern genes. (B) The overlaps between 84 Gata3 targets in ChIP-seq with ABA ISH annotations and Shh+Ptch1−-/Shh−Ptch1+-pattern genes. (C–D) The overlaps between genes with ABA ISH annotations down- or up-regulated by Gata3-knockdown and Shh+Ptch1−-/Shh−Ptch1+-pattern genes. (* indicates the statistical significance of the overlap, P<0.05, in Fisher's exact test).