Synchronization of Isolated Downstates (K-Complexes) May Be Caused by Cortically-Induced Disruption of Thalamic Spindling
Figure 10
Inducing KCs by abruptly increasing RE IT inactivation (RE IT h).
A, In the original configuration and, B, in the 6 PY neurons projecting to all RE neurons configuration, RE IT h is scaled to 40% of its original value (purple asterisks) at 1 s (vertical black line). In other words, the proportion of deinactivated IT channels is abruptly decreased. In both cases, this drop in RE IT h leads to a decrease in PY to RE currents and TC IT, as well as a drop in RE and TC spindling (red asterisks), which ultimately leads to a KC, as indicated by decreased PY spiking (“KC”).