Synchronization of Isolated Downstates (K-Complexes) May Be Caused by Cortically-Induced Disruption of Thalamic Spindling
Figure 4
Characteristics of a single spontaneous KC.
A KC generated when 15 PY neurons projected to all RE neurons. For each of the neuronal populations, the membrane potential of the individual neurons (Vm), the average membrane potential (Avg Vm), the spiking of a single neuron (Cell), and the average spiking rate (Avg Spikes/Sec) are pictured. In addition, high gamma power is plotted for PY neurons and spindle power is plotted for RE and TC neurons. The KC is characterized by a cessation of firing by all cell types, with a drop in membrane potential (blue asterisks), and high gamma power (black asterisk) in PY neurons. The model exhibited spindling (green asterisks), which dropped in the RE and TC neurons during the cortical KC (red asterisks). The red arrow indicates the 15 PY neurons that are connected to all RE neurons, and the red vertical lines mark the start of RE spindle disruption. The membrane potential color scale displayed in the middle of the figure is the same for all cell populations.