Synchronization of Isolated Downstates (K-Complexes) May Be Caused by Cortically-Induced Disruption of Thalamic Spindling
Figure 3
Network geometry and altered projections of thalamocortical model.
A, The network contained 100 PY, 25 IN, 50 TC, and 50 RE neurons. The number of projections between PY and RE neurons was altered to test two ways of evoking KCs. B, In the original network geometry, each PY neuron projected to 5 RE neurons. To evoke KCs, all RE neurons were depolarized. C, In the altered connectivity, a subset of PY neurons projected to all RE neurons, while the remaining PY neurons projected to 5 RE neurons. To evoke KCs, only the PY neurons projecting to all RE neurons were stimulated.