Synchronization of Isolated Downstates (K-Complexes) May Be Caused by Cortically-Induced Disruption of Thalamic Spindling
Figure 2
Bipolar SEEG recordings illustrate widespread spontaneous KC quasi-synchrony across lobes and hemispheres.
Single spontaneous (dashed lines) and averaged (solid lines) KCs detected on Fz for each patient and computed for each selected pair of bipolar contacts. The color of each waveform corresponds to the colored arrow indicating its location on the reconstructed hemispheres and coronal MRI sections for each patient. A, A single trial and the average of 70 KCs for Patient 2 with contacts across the frontal, temporal, and parietal lobes. On average, there is a 32 ms delay between the anterior (inferior frontal sulcus, LbiFg) and posterior (angular gyrus, LAng) channels shown by the yellow arrows. B, A single trial and the average of 129 KCs for Patient 3 with contacts in both hemispheres. The yellow arrow marks mirrored locations in the left and right superior frontal gyrus (RsFg and LsFg), which have an average KC peak latency delay of 2 ms. C, A single trial and the average of 172 KCs for Patient 4 with contacts in both hemispheres for subfrontal and frontal regions. In mirrored sites in the left and right precentral sulcus (LpCs and RpCs), highlighted by the yellow arrow, there is an average 18 ms peak latency difference.