The Structural Basis of ATP as an Allosteric Modulator
Figure 2
Comparison of evolutionary conservation of allosteric and substrate ATP-binding sites.
(A) Distributions of conservation scores for residues in the allosteric and substrate ATP-binding sites as well as in the surface of proteins. (B) Distributions of average conservation scores for residues in the substrate and allosteric ATP-binding sites and the surface per protein. The statistical significant (P-value) was calculated by the Mann-Whitney U test.