eMatchSite: Sequence Order-Independent Structure Alignments of Ligand Binding Pockets in Protein Models
Figure 5
Performance comparison for eMatchSite, PocketMatch, SiteEngine and sup-CK.
Binding site matching is conducted using the (A–C) Kahraman and (D–F) Homogeneous datasets. The accuracy of local alignment predictors is compared to that using global sequence and structure alignments for (A, D) crystal target structures, (B, E) high-, and (C, F) moderate-quality protein models. TPR and FPR are the true and false positive rates, respectively; gray area corresponds to a random prediction.