Characterizing Protein Interactions Employing a Genome-Wide siRNA Cellular Phenotyping Screen
Figure 3
a) Receiver Operating Characteristics curves for the predictions of activation.
Cross-validation results for all pathways combined (AUC = 0.75, dashed line) and when training and validation was done for each set of pathways separately (AUC = 0.82, solid line). b) Histogram of the votes for activating PPIs (green) and inhibiting PPIs (blue) when training and validation was done for each set of major signaling pathways separately. The thresholds for 80% confidence were set at 920 and 88 votes for activation and inhibition, respectively (dashed lines).