SANTA: Quantifying the Functional Content of Molecular Networks
Figure 7
Knet identifies the most functionally informative network.
Association of genes essential in the proliferation of cancer cell lines with a network of curated physical interactions (IntAct) and a functional network created using 21 data sources (HumanNet). Association was stronger between colon and ovarian cancer cell line RNAi hits and the functional network, indicating that the functional network provides more information about the mechanisms that drive cancer cell line maintenance.