A New Model for Pore Formation by Cholesterol-Dependent Cytolysins
Figure 3
Twist of Domain 2 and its influence on Domain 4 orientation.
A. Variations in Domain 4 orientation across the CDC family. Superposition is the same as Figure 2A. Only four representative structures are shown, which cover the entire range of Domain 4 orientation in CDCs. B. Coupling between Domain 2 twist and Domain 4 orientation. Domain 3 is omitted for clarity.