Construction and Validation of a Regulatory Network for Pluripotency and Self-Renewal of Mouse Embryonic Stem Cells
Figure 6
Computational in silico knockdowns of all possible single and double perturbations linked to predicted lineage differentiation outcomes.
(A, C) Predicted lineage specification based on dynamical model simulations. (B, D) Lineage predictions based on direct effects of knockdowns. Predictions are based on differentially expressed genes from LOF studies and promoter binding of transcription factors to differentially expressed genes based on mESC ChIP-chip/seq studies from the ESCAPE database.