Tracing the Evolution of Lineage-Specific Transcription Factor Binding Sites in a Birth-Death Framework
Figure 3
Within-species variation of binding sites according to time of origin.
Boxplots show the fraction of TFBSs containing common SNPs in humans [72], where plots show the median (center line), upper- and lower-quartile (boxes), and range (whisker extremes) of percentages across the TFBSs of six TFs. TFBSs are categorized as human-specific, hominid-specific (not including human-specific sites), Simian primate-specific (not including hominid-specific sites), and ancestral (present in the human-mouse common ancestor). Overall fractions (including all sites) are shown in the left-most boxplot. Note the substantial rise in the amount of human variation within more recently derived binding sites compared to older sites.