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A Hepatitis C Virus Infection Model with Time-Varying Drug Effectiveness: Solution and Analysis

Figure 2

HCV viral load undergoes biphasic decay upon initiation of silibinin treatment at time .

The transition time between the first and second phases, , is calculated by maximizing the curvature in equation (14), and is marked by a vertical dashed line. VE model fit of Canini et al. [19] (solid line) and HCV viral load data (dots) for (a) Patient 46, with transition time days, and for (b) Patient 48, with transition time days.

doi: https://doi.org/10.1371/journal.pcbi.1003769.g002