Hotspot Mutations in KIT Receptor Differentially Modulate Its Allosterically Coupled Conformational Dynamics: Impact on Activation and Drug Sensitivity
Figure 10
Independent dynamic segments identified in KIT cytoplasmic region.
Structural mapping of the Independent Dynamic Segments (IDSs) identified in KITWT and KITmutants. The average conformations are presented as tubes. The size of the tube is proportional to the by-residue atomic fluctuations computed on the backbone atoms. IDSs are referred to as , where i = 1, 2…10, labeled in KITWT and specified by color retained for the IDSs in mutants. The largely modified or newly found IDSs in the mutants are referred to as
.