Propagating Waves of Directionality and Coordination Orchestrate Collective Cell Migration
Figure 6
Association among the waves for DA3 tumor cells exposed to HGF/SF.
(A, C): The association between the waves of acceleration and directionality; (B, D): the association between the waves of directionality and coordination. (A) Scatter plot comparison of directionality vs. acceleration. Each dot in a scatter plot represents an element (t,d) in the two corresponding spatiotemporal maps, accumulated over all the experimental replicates (N = 5). (B) Similar to (A) but for the coordination vs. directionality. (C) Cross correlation between acceleration and directionality. The graph shows the Pearson correlation for different time shifts computed between the spatiotemporal maps of acceleration and directionality accumulated for all the experiments. (D) Cross correlation between the spatiotemporal maps of directionality and coordination accumulated for all the experiments. Inset: cross correlation between a spatiotemporal map of directionality and coordination demonstrating about 30 minutes time shift for a specific experiment.