Communication Routes in ARID Domains between Distal Residues in Helix 5 and the DNA-Binding Loops
Figure 7
FCA modes of L1 and L2 in wt ARID3AFREE or DriDNA and their mutants.
Upper panels) The two panels show the projection along FCA mode 1 and FCA mode 2 for L1 and L2 in ARID3AFREE and its mutants. ARID3AFREE, ARID3AY119A, ARID3AQ111A and ARID3AQ111N are shown with different shade of colors. Bottom panels) The two panels show the projection along FCA mode 1 and FCA mode 2 for L1 and L2 in DriDNA and its mutants. DriDNA, DriY119A, DriQ111A and DriQ111N are shown with different shade of colors. The projections report one replicate of each system, for sake of clarity. The same analysis was carried out for each combination of replicates of wild type and mutant variants and it provides similar results, as also expected by the high overlap in the essential subspace between individual replicates of the same system (root mean square inner product larger than 0.8).