Communication Routes in ARID Domains between Distal Residues in Helix 5 and the DNA-Binding Loops
Figure 3
Evolution of the size of the largest cluster (cluster 1) as a function of the Imin values in Dri and ARID3A simulations.
The Icrit value for the PSN analysis was calculated for each of the simulations collected in this study, included wild-type, mutant variants and DNA-bound structures. The analyses point out the consistency of this parameter within proteins sharing the same fold but different primary sequences, as well as in their DNA-bound and DNA-unbound state, as also previously pointed out for similar analysis on single PDB structures [17].