Regulation of the Nucleosome Repeat Length In Vivo by the DNA Sequence, Protein Concentrations and Long-Range Interactions
Figure 2
NRL as a function of thermodynamic parameters such as the concentration of bound nucleosome core particles (A), maximum allowed length of DNA unwrapping from the nucleosome (B), contact cooperativity between nucleosomes (C), long-range anti-cooperativity between neighboring nucleosomes (D), ratio of linker histone per nucleosome (with m(linker) = 15 bp) (E), and the effective size of the linker protein in terms of covered DNA base pairs (F).
Unless stated otherwise in the figure, the following parameters were used: KNCP* c0(NCP) = 0.7; Klinker = 2·109 M−1.