Locating the Route of Entry and Binding Sites of Benzocaine and Phenytoin in a Bacterial Voltage Gated Sodium Channel
Figure 3
Snapshots of the most commonly sampled binding poses.
The drug and surrounding residues are shown. The residues with the strongest interactions with the drug are named in bold. (A) benzocaine in the activation gate with amine pointing at the central cavity. (B) benzocaine in the activation gate with amine pointing down. (C) benzocaine in a fenestration with amine pointing to the central cavity. (D) Benzocaine in a fenestration with amine pointing toward the lipid. (E) Phenytoin in the activation gate. (F) Phenytoin in a fenestration.