Computational Modeling of Allosteric Regulation in the Hsp90 Chaperones: A Statistical Ensemble Analysis of Protein Structure Networks and Allosteric Communications
Figure 10
The Frequency Distributions of the Network Centrality Parameters in Hsp90 Structures.
The frequency distributions of the betweenness values are shown in different functional states of Hsp90: (A) the apo-HtpG structure (red bars); (B) the ADP-HtpG structure (green bars), (C) the yeast ATP-Hsp90 structure (brown bars), and (D) the ATP-Grp94 structure (orange bars). The residue-based betweenness distributions point to small-world organization of the interaction networks in the Hsp90 structures.