Integrating Diverse Datasets Improves Developmental Enhancer Prediction
Figure 6
Predicted tissue-specific enhancers exhibit tissue-specific characteristics.
EnhancerFinder identifies thousands of novel high-confidence (FPR<0.05) heart, brain, and limb enhancers. These enhancers are enriched for tissue-specific GO Biological Processes. The five most enriched GO Biological Processes among genes near each enhancer set (as calculated using GREAT) are listed in the colored boxes. Nearly 90% of EnhancerFinder predicted heart, brain, and limb enhancers are unique to a single tissue. The larger number of high-confidence heart enhancers relative to brain and limb enhancers is the result of the superior performance of the heart classifier.