BiP Clustering Facilitates Protein Folding in the Endoplasmic Reticulum
Figure 2
Schematic of the processes in the ER and their spatial location.
Protein translocation occurs at the ER membrane, while the other processes can occur in the ER lumen. Processes include: (a) translocation; (b) folding/unfolding/misfolding; (c) aggregation; (d) disaggregation; (e) sequestration. Species are represented as follows: nascent protein (N); folded protein (F); unfolded protein (U); misfolded protein (M); BiP; Translocation Pore (Sec61); Sec63; size 2 aggregate (A2); size 3 aggregate (A3); size 4 aggregate (A4).