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Comparison of REST Cistromes across Human Cell Types Reveals Common and Context-Specific Functions

Figure 1

REST binding in H1-neurons and T cells.

(A) Top motifs identified in T cell ChIP-seq peaks by MEME: (top) cRE1 and (bottom) left and right half-sites of the ncRE1. (B) Distribution of peaks with RE1 motifs. (C) Genomic distribution of REST peaks. (D) Pathways enriched in the REST-bound genes in T cells and neurons, from GREAT [39]; data from “Pathway Commons” were shown and presented as fold enrichment (all p-values≤1.35E-15).

Figure 1

doi: https://doi.org/10.1371/journal.pcbi.1003671.g001