Quantification of HTLV-1 Clonality and TCR Diversity
Figure 4
Comparison of estimators: Effect of sample size on estimated diversity.
Normalized gradients measuring proportional increase in estimated diversity against proportional increase in sample size. Normalized gradients (shown for each estimator and each patient data set in Table S1) were calculated by linear regression. For the HTLV-1 and microbial data, all estimators except DivE show large normalized gradients that are significantly positive. The TCR normalized gradients, though significantly positive, are small and do not show a substantial bias with sample size. *, **, and *** signify p<0.01, p<0.001, and p<0.0001 respectively; two-tailed binomial test (n = 14, 16, 20 for the HTLV-1, TCR and microbial data respectively).