Quantifying the Length and Variance of the Eukaryotic Cell Cycle Phases by a Stochastic Model and Dual Nucleoside Pulse Labelling
Figure 1
A: Scheme of the proposed cell cycle model with three phases
and
The dashed border between the
and the
phase indicates that the
and
phase are pooled into a single phase. The random time
a cell needs to complete the processes associated to each of the phases, follows a delayed exponential distribution with specific parameters
and
for each phase. B: Delayed-exponential completion time distribution density
with parameters
and
C: Best fit of the complementary cumulative distribution
to the fraction of undivided cells after birth obtained by time lapse cinematography [5] of slow and fast dividing cell lines. D: Best fit of
defined by Eq. 4 (solid line) to inter-mitotic time distribution density measured by long-term video tracking of in vitro proliferating B-cells [10]. The data in C and D were read from the graphs in the original publications ([5] and [10] respectively).