Pierced Lasso Bundles Are a New Class of Knot-like Motifs
Figure 5
The threading mechanism of the N-terminal PLB proteins.
(A) The threading mechanism for mIL-3 where slipknotting is the major event (black). We also observe cases where the C-terminal region remains random and no apparent lasso crossing is observed (see cartoon). Panels B-D show the predominance of the plugging mechanism for hIL-3, IFNϕ-1 and IFNϕ-2, respectively. In this mechanism the C-terminal pierces through the N-terminal loop as is shown in the cartoon. As in (A) we also observe cases where the C-terminal region remains random and no apparent lasso crossing is observed (see cartoon).